SANGKURIANG CATFISH (CLARIAS GARIEPINUS VAR) SKIN EXTRACT ACTIVITY ON FIBROBLAST AND COLLAGEN SYNTHESIS FOR SKIN BURN HEALING

Abstract

Burn healing of IIb degree requires a relatively longer time for healing followed by hypertrophic scar formation. Sangkuriang catfish (Clarias gariepinus var) skin extract topical contains amino acids of collagen. Collagen is the main component of skin wound healing. The aim of this research was to determine the influence of Sangkuriang catfish skin extract topical treatment on fibroblast and collagen synthesis for burn healing Methods: Sangkuriang catfish skin was extracted using HCl 2% for 48 hours and neutralized by NaOH 1 M. Twenty-eight male Rattus novergicus strain Wistar were used for this researchwere, divided into K3, P3, K10, and P10 groups. Each member of group was subjected with IIb degree burn injury on the back, then K3 and K10 groups were treated by using aquades topically twice a day whereas P3 and P10 groups tpicaly treated with Sangkuriang catfish skin extract twice a day.