Correlation Of Triglyceride Serum Levels To Estimated Glomerular Filtration Rate (Egfr) In Patients With Chronic Renal Failure At Jemursari Islamic Hospital Surabaya
Keywords:
Chronic renal failure, Triglycerides, eGFR, GPO-PAP (Glycerol Phospat Oxidase-Para Amino Phenazone)Abstract
Chronic renal failure (CRF) is a progressive and irreversible decrease in kidney function. One risk
factor that affects the progression of chronic renal failure is dyslipidemia. Dyslipidemia occurs due to
abnormalities of lipid metabolisms in patient with CRF. Dyslipidemia is characterized by increased levels of
total cholesterol, LDL cholesterol, triglycerides, and decreased HDL cholesterol levels. eGFR is a parameter for
assessing excretion function, by calculating the amount of filtrate produced by the renal glomerulus. The degree
of decrease in eGFR indicates the severity of renal damage. This study aims to determine the relationship of
serum triglyceride levels with eGFR in patient with CRF at Jemursari Islamic Hospital in Surabaya. This type of
research is descriptive experimental with cross-sectional design. The study population was patients with chronic
renal failure, outpatient and hospitalization at Jemursari Islamic Hospital in Surabaya as many as 25 serum
samples. As much as 12% of patients are in the 40 – 50 year age category, 36% are 51 – 60 years old, 44% are
61 – 70 years old, and 8% are 71 – 80 years old. Seventy-two percent of patients are male. The mean triglyceride
level was 146,68 mg/dL and the average eGFR was 19,86 mL/min/1,73m2. The relationships between
triglyceride levels and eGFR was carried out by the Spearman-rho test obtained by the value r = -0,442 and ρ =
0,027. It was concluded that there is a significant negative correlation between serum triglyceride levels and
eGFR in patients with chronic renal failure at Jemursari Islamic Hospital Surabaya.
References
Guyton H. Textbook of Medical Physiology. 11st ed. Pennsylvania: Elsevier Saunders; 2006.
Barret Kim E, Barman SM, Boitano S, Brooks HL. Buku Ajar Fisiologi Kedokteran Ganong.
th ed. Jakarta: EGC; 2015.
RI KK. Riset Kesehatan Dasar (Riskesdas 2013). Jakarta:, Badan Penelitian dan
Pengembangan Kesehatan; 2013.
Nugraha G. LIPID : Klasifikasi, Metabolisme, Aterosklerosis, dan analisis Laboratorium
Jakarta: Trans Info Media; 2017.
Bhagaskara, Liana P, Santoso B. Hubungan Kadar Lipid dengan Kadar Ureum&Kreatinin
Pasien Gagal Ginjal Kronik di RSUP Dr. Mohammad Hoesin Palembang Periode 1 Januari-31
Desember 2013. Jurnal Kedokteran dan Kesehatan. 2015; 2(2): p. 223-230.
Bulum T, Kolaric B, Prkacin I, Duvnjak L. Total and LDL Cholesterol are Associated with
Glomerular Filtration Rate in Normoalbuminuric Type 1 Diabetic Patients. 2013; 37(3): p.
-776.
Nugraha G. Penuntun Praktikum Kimia Klinik I Surabaya: Universitas Nahdlatul Ulama
Surabaya; 2017.
Sevilla C. Research Methods Quezon City: Rex Printing Company; 2007.
Weinstein J R, Anderson S. The Aging Kidney: Physiologycal Changes. 2010; 17(4): p. 302-
Anonimus. 5th Report of Indonesian Renal Registry.
Scales C D, Smith, A C, Hanley J M, Saigal, C.S. Prevalence of Kidney Stone in the United
States. Neurology. 2012; 62(1): p. 160-165.
Effendi I, Markum H. Pemeriksaan Penunjang pada Penyakit Ginjal Jakarta: Interna
Publishing; 2006.
Verdiansah. Pemeriksaan Fungsi Ginjal. Jurnal CKD. 2016; 43(2): p.148-154.
Toussaint. Screening for Early Chronic Kidney Disease Australia: Saunder; 2012.
Chan CM. Hyperlipidemia in Chronic Kidney Disease. 2005; 1.
Agarwal R. Effects on Statins on Renal Function. In Mayo Clinic Proceedings; 2007. p. 1381-
Senge C E, Moeis E Sy, Sugeng, CEC. Hubungan Kadar Lipid Serum dengan Nilai Estimasi
Laju Filtrasi Glomerulus pada Penyakit Ginjal Kronik. Jurnal eClinic (eCl). 2017; 5(1): p. 44-
