The Effect Of Long Exposure To Pesticide Organophosphate On Cholinesterase Enzyme Activity In The Blood
Keywords:
Operators of Pesticide Production, Levels of Cholinesterase Enzymes, Organophosphates, Photometric Kinetic TestsAbstract
The high use of pesticides increases the health risks faced, both for pesticide operators and the community
at large. Synthetic group pesticides that are widely used by farmers in Indonesia are organophosphate groups. These
organophosphate compounds are unstable in the environment but are more toxic to vertebrate animals because they
can affect the nervous system by inhibiting cholinesterase enzyme activity in the body. The purpose of this study was
to analyze the effect of exposure to organophosphate pesticides on the activity of cholinesterase enzymes in the
blood of factory workers in fertilizer and pesticide industries. This study used an observational analytic study design
with cross sectional design. The sample of this study was the pesticide production operator which amounted to 15
respondents who had different lengths of work taking blood for the examination of cholinesterase enzymes using the
method of kinetic photometric test method recommended by the German Society of Clinical Chemistry (DGKC).
Data analysis techniques with One Way Anova test. The results of the examination of the respondents cholinesterase
levels showed a value between 5981 U/L - 12006 U/L which was categorized as mild and normal poisoning. The
One Way Anova test results obtained the length of work of <10 years old work obtained an average value of 8798.5
U/L, working duration of 10-15 years obtained an average value of 7166.6 U/L, length of work > 15 years obtained
an average value of 8264.0 U/L, with a p value (0.396) > 0.05 it can be concluded that there is no effect on the
duration of exposure to organophosphate pesticides in the decrease in cholinesterase enzyme activity in the blood of
pesticide production operators.
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